58 research outputs found
LAVIS: A Library for Language-Vision Intelligence
We introduce LAVIS, an open-source deep learning library for LAnguage-VISion
research and applications. LAVIS aims to serve as a one-stop comprehensive
library that brings recent advancements in the language-vision field accessible
for researchers and practitioners, as well as fertilizing future research and
development. It features a unified interface to easily access state-of-the-art
image-language, video-language models and common datasets. LAVIS supports
training, evaluation and benchmarking on a rich variety of tasks, including
multimodal classification, retrieval, captioning, visual question answering,
dialogue and pre-training. In the meantime, the library is also highly
extensible and configurable, facilitating future development and customization.
In this technical report, we describe design principles, key components and
functionalities of the library, and also present benchmarking results across
common language-vision tasks. The library is available at:
https://github.com/salesforce/LAVIS.Comment: Preprint of LAVIS technical repor
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Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL-5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL
The Fip1-like1 (FIP1L1)–platelet-derived growth factor receptor alpha (PDGFRA) (F/P) oncogene can cause chronic eosinophilic leukemia (CEL), but requires IL-5 cytokine participation. In this study, we investigate the mechanism of F/P in collaboration with IL-5 in CEL. The results showed that Lyn, a key effector in the IL-5-motivated eosinophil production, is extensively activated in F/P-positive CEL cells. Lyn can associate and phosphorylate IL-5 receptor α (IL-5RA) in F/P-positive cells. Moreover, the activation of Lyn and IL-5R kinase were strengthened when the cells were stimulated by IL-5. Lyn inhibition in F/P-positive CEL cells attenuated cellular proliferation, induced apoptosis, and blocked cell migration and major basic protein (MBP) release. We identified the FIP1L1-PDGFRA/JAK2/Lyn/Akt complex in the F/P-expressing cells which can be disrupted by dual inhibition of JAK2 and Lyn, repressing cell proliferation in both EOL-1(F/P-positive human eosinophilic cell line) and imatinib-resistance (IR) cells. Altogether, our data demonstrate that Lyn is a vital downstream kinase activated by F/P converged with IL-5 signals in CEL cells. Lyn activate and expand IL-5RA intracellular signaling through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex, provoking eosinophils proliferation and exaggerated activation manifested as CEL
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